ANALISIS FISIOLOGI PERNAPASAN PADA KONDISI HIPERTENSI DAN ASMA

Authors

  • Annisa Triharta Ritonga Universitas Islam Negeri Sumatera Utara
  • Alya Salsabila Nasution Universitas Islam Negeri Sumatera Utara
  • M.Fahrizal Ramadhan Universitas Islam Negeri Sumatera Utara
  • Haafizhah Husnah Universitas Islam Negeri Sumatera Utara
  • Rini Andriyani Universitas Islam Negeri Sumatera Utara
  • Fadila Susanri Pulungan Universitas Islam Negeri Sumatera Utara
  • Irfan Sazali Nasution Universitas Islam Negeri Sumatera Utara

DOI:

https://doi.org/10.61722/jipm.v2i3.241

Abstract

Abstract. This study aims to analyze respiratory physiology in patients with hypertension and asthma, as well as the pathophysiological interactions between these two diseases. An observational study was conducted on 200 patients consisting of 50 hypertension patients, 50 asthma patients, 50 patients with hypertension and asthma, and 50 healthy controls. Parameters measured include lung function (FEV1, FVC, PEFR), blood pressure, lung diffusion capacity, and systemic inflammatory biomarkers. The results showed that patients with hypertension experienced a 15% reduction in lung diffusion capacity compared to controls (p<0.01). Asthma patients showed a decrease in FEV1 and PEFR of 25% and 30% respectively (p<0.001). In the hypertension and asthma group, an additive effect was found with a more significant reduction in lung function (FEV1: -35%, PEFR: -40%, p<0.001) and an increase in systemic inflammatory biomarkers (CRP: +45%, p<0.01). Multivariate regression analysis showed a positive correlation between the severity of hypertension and decreased lung function in asthma patients (r=0.68, p<0.001). In conclusion, there is a significant pathophysiological interaction between hypertension and asthma that impacts respiratory physiology. These findings emphasize the importance of an integrated approach in the management of patients with both conditions.

References

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Published

2024-06-25

How to Cite

Annisa Triharta Ritonga, Alya Salsabila Nasution, M.Fahrizal Ramadhan, Haafizhah Husnah, Rini Andriyani, Fadila Susanri Pulungan, & Irfan Sazali Nasution. (2024). ANALISIS FISIOLOGI PERNAPASAN PADA KONDISI HIPERTENSI DAN ASMA. JURNAL ILMIAH PENELITIAN MAHASISWA, 2(3), 836–842. https://doi.org/10.61722/jipm.v2i3.241

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Vol. 2 No. 3 (2024): Juni

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